![]() ![]() In fact, a hallmark of cancer is its unlimited replicative capacity, which can be achieved through the activation of so-called telomere maintenance mechanisms. In cancer, this same process is overcome by the cancer cells in order to initiate and support cancer growth. This process is physiologically due to the inability of somatic cells to polymerize all DNA during replication. In somatic cellular compartment, each round of cell division is accompanied by telomere shortening. In these neoplasms, ALT should be taken into account for a precise prognostic stratification and design of potential therapeutic strategies. ![]() Our results indicate that ALT is associated with an increased risk of death in patients with sarcoma. In fact, ALT+ patients showed a statistically significant higher risk of death than ALT- patients, when also considering data from multivariate analyses (RR = 1.50 95% CI: 1.15–1.96 p = 0.003 HR = 2.02 95% CI: 1.22–3.38 p = 0.007). Furthermore, we demonstrate a strong impact of ALT on survival. The ALT+ group showed a higher mitotic count and a higher tumor grade compared with the ALT- group ( p < 0.01). ![]() ResultsĮight articles comprising a total of 551 patients with sarcomas (226 ALT+ and 325 ALT-) were selected. The secondary outcome was the hazard ratio (HR), adjusted for the maximum number of covariates available, using ALT- patients as reference. total participants during follow-up in ALT+ versus ALT- patients as the primary outcome. ![]() We considered the risk of death (risk ratio, RR) calculated as the number of death vs. We searched SCOPUS and PubMed through July 2018 to identify all studies that investigated the prognostic role of ALT in sarcomas. Therefore, we provide here the first meta-analysis on this topic. ALT has been described in different types of sarcoma, but a comprehensive analysis of its clinical significance is still lacking. Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |